3R Day – Models in Biomedical Research SATELLITE SEMINAR (Remote) | 14 October 2024 | 14:00 | Auditorium Corino de Andrade - i3S

SYSTEMATIC REVIEW & META-ANALYSIS TO SUPPORT THE 3Rs AND BEYOND IN BIOMEDICINE

Alexandra Bannach-Brown

Alexandra Bannach-Brown

CAMARADES BERLIN Preclinical Systematic Review & Meta-Analysis, Berlin Institute of Health at Charité (BIH) BIH QUEST Center for Responsible Research

Host: Marta Teixeira Pinto and Susana Magalhães

The Institute for Research and Innovation in Health (i3S) and the Portuguese Reproducibility Network (PTRN) are pleased to announce the Webinar " Systematic Review & Meta-Analysis to support the 3Rs and beyond in biomedicine" by Alexandra Bannach-Brown, at the auditorium Corino de Andrade (i3S) on 14th October, 14.00-15.00H.

After the talk, don't miss the opportunity to participate in a in live round table discussion on how systematic reviews can be a powerful tool for better implementing the 3R principles in biomedical animal experimentation.  The round table, moderated by Susana Magalhães (i3S) and will include Nuno Franco (i3S, ETPLAS, ORBEA, SPCAL), Teresa Summavielle (i3S, CARE committee at FENS) and  Luis  Azevedo (MEDCIDS, FMUP)  as featured participants.

For further information on the seminar and the speaker, please see below:

Abstract

This talk highlights the role of systematic reviews and meta-analyses in promoting the 6Rs (Replacement, Reduction, Refinement, Robustness, Registration, and Reporting) in biomedical research. While the 3Rs focus on animal welfare, the expanded 6Rs ensure ethical research also yields valuable scientific and societal outcomes. A systematic review is a research method that comprehensively and systematically synthesises existing evidence on a specific topic using reproducible procedures to minimise bias. Systematic reviews help address issues like poor study design, publication bias, and reporting, ensuring that new animal experiments fill relevant knowledge gaps and improve research generalizability. CAMARADES, a global network, supports systematic reviews and meta-analyses in preclinical research, and works to overcome the challenges of conducting systematic review research such as resource demands and biases in existing literature. Communities for Open Research Synthesis are being created to support systematic reviews and meta-analyses in the field of preclinical research, consisting of researchers, evidence synthesis statisticians, and specialists who work together to perform systematic reviews and inform future studies.

Short Bio

Dr. Bannach-Brown is a methodologist at the QUEST Center, Berlin Institute of Health at Charité. Within the CAMARDES Berlin team, she develops and delivers preclinical systematic review education and provides methodological support to researchers carrying out systematic reviews of preclinical data. She conducts systematic review in animal models of psychiatry and has specialized expertise in applying automation techniques and software for systematic review.

More information about the CAMARADES Berlin group can be found on the Berlin Institute of Health website:  https://www.bihealth.org/en/quest/service/service/camarades-facility-for-the-systematic-review-and-meta-analysis-1